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SARMs, melanocortin peptides, and GLP-1/metabolic compounds researched for body composition, pigmentation, and weight management.
This category is really three different things filed under one roof: SARMs (RAD-140, LGD-4033, Ostarine, and others) for muscle and body composition, GLP-1/metabolic compounds (Retatrutide, Tirzepatide, Cagrilintide, IGF-1 LR3, HCG) for weight and metabolic research, and a mixed group of melanocortins, PCT compounds, and miscellaneous items (Melanotan I/II, PT-141, Enclomiphene, Anastrozole, and others) that don't fit neatly elsewhere. None of these are FDA-approved for general human use — they're sold as research chemicals, studied for over 20 years in the case of SARMs without a single one reaching approval. If you're coming from a SARM or steroid cycle, the PCT compounds in this category exist specifically to help restart natural testosterone production afterward, since that suppression is a real, documented effect rather than a rare edge case.
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Not for human use. The FDA hasn't approved any SARM, and they can't legally be sold as dietary supplements — they're sold as research chemicals for laboratory use, a very different legal category than an approved or even grey-area supplement.
Yes, to varying degrees. They bind androgen receptors strongly enough to signal your brain to reduce LH and FSH — the hormones telling your body to produce testosterone naturally — which is exactly why post-cycle therapy (commonly Clomid or Nolvadex) comes up so often in SARM discussions.
One extra target. Tirzepatide hits two receptors — GLP-1 and GIP. Retatrutide hits three — GLP-1, GIP, and glucagon. That third target is what pushes resting energy expenditure and liver fat-burning higher, the mechanistic reason retatrutide is outperforming tirzepatide on weight loss in trials so far.
Fair question — HCG's best-known clinical use is fertility-related, but it also shows up in body-composition and PCT contexts because of its effect on the testes and hormone signaling, which is why it sits alongside metabolic compounds here.
Selectivity is the whole story. Melanotan 1 is highly selective for just one receptor (MC1R), tied specifically to skin pigment, so effects stay mostly limited to tanning. Melanotan 2 is far broader, hitting MC1R plus three other melanocortin receptors, which is why it also affects appetite and sexual function beyond skin color.
Because they're doing cleanup work after a SARM or steroid cycle rather than driving growth themselves — since compounds in this category can suppress natural testosterone production, these are what people research to help restart it afterward, filed alongside the compounds that created the problem in the first place.