
IGF-1 DES(1-3) is a truncated variant of IGF-1 LR3 — three amino acids shorter, at 67 residues instead of LR3's 83. That shorter N-terminus actually increases its binding affinity at the IGF-1 receptor roughly tenfold, but it clears the body in 20-30 minutes versus LR3's 20-30 hours, making its action far more localized and short-lived than LR3's extended systemic exposure.
No — same parent hormone, different modification. DES removes three N-terminal amino acids for a short, potent, localized effect; LR3 adds amino acids for a long, systemic one.
DES has higher intrinsic receptor affinity, but LR3's much longer half-life gives it more total systemic exposure over time. "More potent" depends on which effect (peak local activity vs. sustained circulating levels) is being measured.
No. It is not an approved drug in any form and is sold for research use only.
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