
MGF (Mechano Growth Factor) is a splice variant of IGF-1 that skeletal muscle produces locally in response to mechanical loading or damage — an autocrine/paracrine signal, not a systemic hormone. It's studied for activating satellite cells (muscle stem cells), the process muscle repair and hypertrophy depends on.
IGF-1 LR3 circulates systemically and has a long half-life. MGF is produced locally by muscle tissue itself in response to damage or mechanical stress, acting where it's made rather than throughout the body.
No. It is not an approved drug and is sold for research use only.
PEG-MGF is the pegylated form — polyethylene glycol chains extend its half-life from minutes to roughly 24 hours, making it more practical to dose in a research setting.
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