LGD-4033 (Ligandrol) is one of the more clinically studied SARMs, having a published Phase 1 human trial that showed dose-dependent increases in lean mass alongside suppression of natural testosterone and HDL cholesterol at higher doses, both of which reversed after stopping. It has no approved medical use.
Benefits
LGD-4033 (Ligandrol) is a nonsteroidal, oral selective androgen receptor modulator (SARM) — one of the few compounds in this SARM category with an actual published Phase 1 human trial, often cited as the most-referenced SARM trial in the literature.
Human Phase 1 trial (n=76 healthy men, 21-50 years, 21 days, doses of 0.1/0.3/1.0mg daily): lean body mass increased dose-dependently (averaging 1.21kg at the 1.0mg dose) without a significant change in fat mass. The compound was well tolerated, with no serious adverse events. Basaria et al., J Gerontol A Biol Sci Med Sci, 2013
Dosage
The human trial tested 0.1mg, 0.3mg, and 1.0mg daily, oral, for 21 days — the highest dose (1.0mg) produced the largest lean-mass gain but also the most pronounced hormone suppression (below).
Side Effects
Dose-dependent suppression of total testosterone and sex hormone-binding globulin was observed, with free testosterone and FSH significantly suppressed specifically at the 1.0mg dose. HDL cholesterol and triglycerides also decreased. Hormone levels and lipids returned to baseline after stopping treatment — the suppression wasn't permanent in this 21-day trial. No significant changes were found in hemoglobin, PSA, liver enzymes, or QT interval at any dose tested. Worth noting this trial only ran 21 days — it doesn't establish what happens with longer-term use.
Has LGD-4033 been tested in humans?+
Yes, a published Phase 1 trial in healthy men showed dose-dependent lean-mass gains alongside testosterone and HDL cholesterol suppression, which reversed after stopping the compound.
Is LGD-4033 FDA-approved?+
No. Despite having more human data than most SARMs, it has not advanced to an approved product.
Is LGD-4033 banned in sport?+
Yes, prohibited under WADA S1.2, and it has been the basis of several high-profile doping violations in professional sport.
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