FDA-approved
Tadalafil (Cialis) is an FDA-approved PDE5 inhibitor (approved 2003), used for erectile dysfunction and benign prostatic hyperplasia. It works by slowing the breakdown of cGMP, promoting smooth-muscle relaxation and blood flow to the penis. Its defining pharmacological difference from sildenafil is duration: roughly a 17.5-hour half-life vs. sildenafil's ~4 hours, which is why it's sometimes marketed for next-day effect rather than same-session use.
Side Effects
As an approved drug with a full label, known risks include headache, flushing, and — the most safety-critical interaction — dangerous blood pressure drops when combined with nitrates (used for chest pain/heart conditions), which is an absolute contraindication, not a minor caution.
Looking for something specific, or placing a wholesale order? Send us a DM or email.