Benefits
GHRP-2 is a synthetic ghrelin-receptor agonist, a GH secretagogue in the same family as GHRP-6 but with a different potency/side-effect profile.
Human trial, appetite (n=7 healthy men, subcutaneous infusion 1mcg/kg/hour for 270 minutes): GHRP-2 increased ad libitum food intake by 35.9% vs. saline (energy intake rising from 101.3 to 136.0 kJ/kg, P=0.008), with no change in what macronutrients were chosen — just how much was eaten. Laferrère et al., J Clin Endocrinol Metab, 2005 Separately, in GH-deficient children on long-term oral GHRP-2, 7 of 10 patients reported significantly increased appetite in the first 6 months.
Regulatory note: not FDA-approved for human therapeutic use in the US, but approved in Japan as a diagnostic agent for GH deficiency — a real, if narrow, regulatory validation most research peptides don't have anywhere.
Side Effects
Appetite stimulation is a consistent, well-documented effect across both trials above — worth framing as an expected pharmacological effect of this specific compound, not an incidental side effect, if the page discusses side effects at all.
GHRP-2 or GHRP-6 — which one actually releases more growth hormone?+
GHRP-2, by a real margin — peak GH levels run roughly 40-60 ng/mL for GHRP-2 versus 25-40 ng/mL for GHRP-6 at matched doses.
Why does GHRP-6 make people so hungry, and does GHRP-2 have that problem?+
GHRP-6 triggers noticeable hunger in 70-80% of people who use it, through the same ghrelin pathway that makes you hungry naturally. GHRP-2 causes hunger in fewer than 20% at a matched dose, which is the main reason people reach for GHRP-2 when hunger is something they're trying to avoid.
Does GHRP-6 raise cortisol more than GHRP-2?+
Yes — roughly 2-3x higher at comparable doses. It's the same tradeoff showing up again: GHRP-6's stronger pathway activation means more hunger and more cortisol riding alongside the GH pulse.
Which is better for someone who just wants GH without the extras?+
GHRP-2 — it's the more selective of the two, producing similar or better GH release while keeping cortisol, prolactin, and appetite effects lower. GHRP-6 makes more sense if hunger stimulation is actually something you want alongside the GH pulse.
Does either one raise prolactin?+
Not really at lower doses — around 100mcg, neither reliably pushes it above normal. At 200-300mcg, GHRP-6 edges slightly ahead, consistent with its less selective profile overall.
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